Florastor Kids Powder by Biocodex

In every child there are billions of microorganisms that keep your gut (intestines) working properly. Some medicines, certain diseases, travel and stress can cause an upset in the balance of microorganisms in your body. Florastor™ promotes and maintains intestinal health and is safe to take with other medicines.

Ingredients and Suggested Use

Ingredients per sachet:

Lyophilized Saccharomyces boulardii from Biocodex.......250 mg

Fructose......472 mg

Lactose......33 mg

Other Ingredients: Tutti-Fruti flavor colloidal anhydrous silica

Suggested Use
1 sachet in the morning, 1 sachet in the evening.

How to prepare: Mix contents of sachet with water, apple juice or other "still" non-carbonated drinks. For babies, add to formula after warmed. Florastor can also be added to apple sauce and other soft baby foods.

Tips from the Nutritionist

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More Info

What is Florastor^®?
Florastor^® is a probiotic made of live freeze dried yeast cells of the species Saccharomyces boulardii. The cells look like a powder which is then put into packets. Each packet of Florastor^® has 250 mg of S. boulardii in it.

BIOCODEX, Inc., commitment to excellence
Biocodex, Inc., has strict manufacturing processes that guarantee each packet of Florastor^® contains live yeast cells. There are multiple checking and test points by no fewer than 16 doctors to ensure that the cells are both "good" and present in the correct amount prior to being sold.

What is a probiotic?
Probiotics help the good organisms in your intestine to grow and protect your intestines against "bad" organisms that can make you unwell.

Why should you take Florastor^®?
To promote and maintain intestinal health and normal bowel function??

Who should take Florastor^® ?
Infants, children, adolescents and even adults if they prefer a powder form.

How many packets of Florastor^® should you take?
Take one packet twice a day unless otherwise instructed by your physician.

How should you take Florastor^®?

Tear open the packet and empty the contents over semi-solid food like apple sauce, sour cream or yogurt OR
Tear open the packet and empty the contents into drinks like water, orange juice, apple juice, milk or formula.

How long does it take for Florastor^® to start to work?
Florastor^® powder dissolves in the stomach 30 minutes after swallowing. The cells then spread through the intestine promoting healthy growth and function.

How long does Florastor^® continue to have an effect after you stop taking it?
When you stop taking Florastor^® S. boulardii cells clear the body within 5 to 7 days.

I have lactose intolerance. Can I still take Florastor^®?
Yes. Florastor^® only contains a small amount of lactose (32.5 mg, this is 1/3rd of the amount of lactose found in 1 slice of cheese) and has been successfully taken by people who can't eat lactose. Florastor^® makes lactase which helps break down lactose. If you have more questions, please speak to your health care professional.

DO NOT take Florastor^® if:
You have a yeast allergy or if you are currently taking any antifungal products (this could stop Florastor^® from working).

If using Florastor^® in children who may be dehydrated:
Replacement of water and electrolytes is recommended.

Are there any side effects from taking Florastor^® ?
Gas, constipation or thirst have been reported infrequently. If you have a central venous catheter, please speak with your health care professional before you start taking Florastor^®. Very rare cases of fungemia have been observed in patients with a central venous catheter. In all cases the course was favorable after antifungal treatment.

Storage:
Florastor^® is guaranteed for up to three years when stored at room temperature (25?? C or 77?? F) or below. No Refrigeration Necessary.

The History of Florastor^®

In the early 1920's in Indochina (Indochina is the peninsula of southeast Asia pictured in blue), French microbiologist Henri Boulard was looking for a new strain of yeast that would withstand extreme heat in order to make good wine. Brewers yeast has a development temperature of 70 degrees Fahrenheit, but Boulard was looking for something more heat resistant.

There was an outbreak of cholera in one of the villages he was traveling through, and he noticed that the local people were stopping the diarrhea by drinking a certain tea. He found out they were taking the skins from a litchi (the litchi comes from the Chinese tree Litchi chinensis that bears bright red fruits, each of which has a large single seed with a white, fleshy, edible aril), cooking the litchi skins and drinking the boiled water as tea.

Henri succeeded in isolating the agent responsible for treating the diarrhea. It was a special strain of yeast of the "Saccharomyces" genus, which he named after himself, "Saccharomyces boulardii."

Biocodex, Paris, France

1947: Mr. Michel Hublot, a doctor of pharmacy, founded Biocodex along with Mr. Francois Vallet, graduate in law. Mr. Henri Boulard met with Biocodex and made arrangements with Biocodex to purchase the rights to his strain of Saccharomyces boulardii and the fermentation process. Biocodex holds the patents on this strain of Saccharomyces and the fermentation process. All research and studies to date have been done on Biocodex's strain of Saccharomyces boulardii lyo.

1966: Building of an ultra-modern factory and research center near Beauvais, France, with the aim of centralizing production to ensure the highest pharmaceutical production and safety standards.

1974: Creation of a new corporate office in Montrouge, France. Biocodex at this time has been successfully promoting Ultra-Levure (Florastor^®) throughout Europe, and to date it is being used in over 80 countries worldwide.

1987: Biocodex, Inc., the first research center in the United States is created in Seattle, Washington. Research and studies are done on Clostridium difficile disease, antibiotic associated diarrhea, and other intestinal health problems.

1990: Opening of a new state-of-the-art Research Center located in Compiegne, France, with modern facilities for research, development, and advancing further studies on this strain of non-pathogenic yeast.

2000: Biocodex, Inc., new corporate office and distribution center for Florastor^® is created in Creswell, Oregon.

Research Review:

Florastor®, one of the main treatments for loose stools in Europe, has been clinically proven and is now available in the United States. Extensive clinical trials in America and Europe support Florastor’s efficacy and safety.

Florastor® contains Saccharomyces boulardii lyo and has been published in major scientific journals such as JAMA, The American Journal of Gastroenterology, Gastroenterology, The BMJ, and many others.

Florastor®, from Biocodex Inc., has been tested and researched in the USA over the last 14 years.

Florastor® Key Points

Florastor® is a probiotic. Probiotics are live microorganisms that produce therapeutic or preventive health benefits. In the US probiotics are considered dietary supplements. Probiotics help to return the body’s intestines back to normal after gastric upset from antibiotic therapy, bacterial and viral infections.

Florastor®, Saccharomyces boulardii, is a natural probiotic that acts as temporary flora and destroys pathogenic (bad) bacteria. This means

decreasing abdominal discomfort
reducing the number of stools
improving the consistency of stools
protecting the intestinal wall
maintaining intestinal function

Florastor® has been clinically researched and is marketed in over 80 countries, guaranteeing you of its safety and efficacy

Florastor® has over 50 years of safety data from patients of all ages from infants to seniors meaning everyone can benefit from Florastor

Biocodexs’ manufacturing process ensures five billion live S. boulardii cells per 250 mg capsule

Florastor® has a three year shelf life due to the high manufacturing standard

Florastor® does not need to be refrigerated as the live cells are freeze dried to be shelf stable

Florastor® is unique; it is non-pathogenic yeast, not bacterium, brewers or bakers yeast, meaning Florastor® is resistant to antibiotics as well as low pH and bile salts

S. boulardii (Florastor® ) is tropical yeast found to develop and work best at 30º C (Celsius), unlike other yeasts that develop at 10º C and 20º C. Florastor® is more likely to have a positive result due to its sustainability at higher temperatures

S. boulardii remains intact as it enters the digestive tract and is resistant to both low pH and bile salts, so its effect can be realized starting in the duodenum

Florastor® is manufactured to the highest ethical pharmaceutical standards and adheres to the CGMP (Certified Good Manufacturing Practice;) you can be confident that what our product states on the label is actually in the bottle

Studies have shown Florastor® to be resistant to many commonly used antibiotics (except antifungal or antimycotics)

Florastor® can be taken with standard antibiotics without any loss of effect or destruction of live S. boulardii cells

What effect does Florastor® have on the intestinal tract?

Saccharomyces boulardii (Florastor®) secretes a 54KDa protein protease, which has been shown to neutralize certain bacterial toxins and prevent the negative bacteria from adhering to the intestinal receptor sites.
Florastor® has been shown to stimulate an immune response in the intestinal mucosa, secretory IgA and IgG, which then helps to strengthen the digestive tract’s defenses against infection.
In studies Florastor® has been shown to increase a trophic or repair effect by enhancing the metabolic structure of the mucosa.
Florastor® releases what are referred to as polyamines: spermine, spermidine and putrescine, which are implicated in stimulating the enzymatic activity of the colonic mucosa in growing, multiplying and repairing of impaired intestinal cells.
When polyamines are released there is an increase in disaccharidases: lactase, sucrase and maltase. The absence of these enzymes can compound certain forms of diarrhea, especially food allergy associated diarrhea.
Florastor® will also re-establish the properties of normal intestinal microflora and normal intestinal balance when any disruption of the ecological system of the intestinal tract occurs.

Can Florastor® be recommended for patients with lactose intolerance?
There is no milk protein found in Florastor® . However, it does contain lactose monohydrate in a very small amount (32.5 mg). Many lactose and dairy sensitive patients have reported good results while taking Florastor® . Florastor® activates the body’s own production of disaccharide enzymes, lactase, sucrase and maltase, which helps digest the lactose. Click here for more information [opens a new window].

Anti-inflammatory activity
1. Florastor® (Saccharomyces boulardii) interferes with enterohemorrhagic Escherichia coli induced signaling pathways in T84 cells. Infection and Immunity 2003; 71: (2) 766-773. S. Dahan, G. Dalmasso, V. Imbert, J. F. Peyron, P. Rampal, D. Czerucka. In a second part of this study, the team showed the action of Saccharomyces boulardii on tight junctions… [Download Entire Article] [opens a new window].
2. Dose response relationship and mechanism of action of Florastor® (Saccharomyces boulardii) in castor oil induced diarrhea in rats. Digestive Diseases and Sciences 2003; 48: (4) 7770-7774. P. Girard, Y. Panssart, I. Lorette, J. M. Gillardin. This model has shown that Saccharomyces boulardii inhibited nitric oxide (NO) formation and hence…[Download Entire Article] [opens a new window].
Antimicrobial activity
1. Florastor® (Saccharomyces boulardii) interferes with enterohemorrhagic Escherichia coli induced signaling pathways in T84 cells. Infection and Immunity 2003; 71: 2: 766-773. S. Dahan, G. Dalmasso, V. Imbert, J. F. Peyron, P. Rampal, D. Czerucka. This study showed that Saccharomyces boulardii reduced the permeability of cells…[Download Entire Article] [opens a new window].
2. Inhibition of in vitro cell adherence of Clostridium difficile by Florastor® (Saccharomyces boulardii). Microbial Pathogenesis 2002; 32: 219-225. A. Tasteyere, M. C. Barc, T. Karjalainen, P. Bourlioux, A. Collignon. These results suggest that the yeast Florastor® (Saccharomyces boulardii) could inhibit adherence of C. diff. to cells…[Download Entire Article] [opens a new window].
3. Florastor® (Saccharomyces boulardii) preserves the barrier function and modulates the signal transduction pathway induced in enteropathogenic Escherichia coli infected T84 cells. Infection and Immunity; 2000: Vol. 68: No. 10: 5998-6004. D. Czerucka, S. Dahan, B. Mograbi, B. Rossi, P. Rampal. Use of the non-pathogenic yeast Florastor® (Saccharomyces boulardii) in the treatment of infectious diarrhea has attracted growing interest. The present study…[Download Entire Article] [opens a new window].
4. Adherence of Escherichia coli serogroup 0 157 and the Salmonella typhimurium DT 104 to the surface of Florastor® (Saccharomyces boulardii). Mycoses 1999; 42: 4: 261-264. B. R. Gedek. In the presence of Saccharomyces boulardii and due to the presence of high concentration of mannose in the outer membrane…[Download Entire Article] [opens a new window].
5. Influence of Florastor® (Saccharomyces boulardii) on cell invasion of Salmonella typhimurium andYersinia enterolitica. Microbial Ecology in Health and Disease; 1999: 11: 158-162. R. Zbinden, M. Altwegg, E. E. Goenczi. In vitro experiments showed that Saccharomyces boulardii reduced the growth of Salmonella typhimurium considerably…[Download Entire Article] [opens a new window].
6. In vitro antagonistic effect of Florastor® (Saccharomyces boulardii) against bacteria involved in diarrhea in intensive care unit patients. Science des Aliments. 1986; 6: (VI): 63-73. E. Bergogone-Berezin, M. Bornet. Bacteria development in enteral nutrition in intensive care wards represents a major risk of contamination in patients…[Download Entire Article] [opens a new window].
7. Comparative effect of a single or continuous administration of Florastor® (Saccharomyces boulardii) on the establishment of various strains of Candida in the digestive tract of gnotobiotic mice. Annales de Microbiologie (Institut Pasteur); 1982: 1338: 491-501. R. Ducluzeau, M. Bensaada. Florastor® (Saccharomyces boulardii) became established in the digestive tract of…[Download Entire Article] [opens a new window].
Enzymatic Activity
1. Florastor® (Saccharomyces boulardii) enhances N-terminal peptide hydrolysis in suckling rat small intestine by endoluminal release of a zinc-binding metalloprotease. Pediatric Research 2002; 51: (4) 528-534. J-P. Buts, et al. Saccharomyces boulardii, when given orally to suckling rats, is able to significantly enhance hydrolysis of N-terminal…[Download Entire Article] [opens a new window].
2. Effects of oral Saccharomyces boulardii on bacterial overgrowth, translocation, and intestinal adaptation after small bowel resection in rats. Scandinavian Journal of Gastroenterology; 2000; 35:160-165. A. Zaouche, C. Loukil, P. De Lagausie, M. Peuchmaur, J. Macry, F. Fitoussi, P. Bernasconi, E. Bingen, J. P. Cezard. Small bowel resection in animals results in alterations of the morphology and functional adaptation in the remaining intestine. The aim of our study was…[Download Entire Article] [opens a new window].
3. Response of human and rat small intestinal mucosa to oral administration of Florastor® (Saccharomyces boulardii). Pediatric Research; 1986: Vol. 20: No. 2. J-P. Buts, P. Bernasconi, M-P. Van Craynest, P. Maldague, R. De Meyer. Abstract: To evaluate the response of the small intestinal mucosa to Saccharomyces boulardii yeast widely used in some countries as an adjuvant drug with oral antimicrobial therapy…[Download Entire Article] [opens a new window].
4. Florastor® (Saccharomyces boulardii) upgrades cellular adaptation after proximal enterectomy in rats. GUT; 1999: Vol. 45: No 1: 89-96. J-P. Buts, N. De Keyser, S. Marandi, D. Hermans, E. M. Sokal, Y-H. E. Chae, L. Lambotte, H. Chanteux, P. M. Tulkens. Saccharomyces boulardii is non-pathogenic yeast which exerts trophic effects on human and rat small intestinal mucosa. Aim: To examine the effects of S. boulardii on ileal adaptation…[Download Entire Article] [opens a new window].
5. Florastor® (Saccharomyces boulardii) enhances rat intestinal enzyme expression by endoluminal release of polyamines. Pediatric Research; 1994: Vol. 36, No. 4. J-P. Buts, N. De Keyser, L. De Raedemaeker. Florastor® (Saccharomyces boulardii) is yeast widely used in humans for the prevention and treatment of infectious enteritis and Clostridium difficile associated entero-colopathies. After oral administration…[Download Entire Article] [opens a new window].
Metabolic Activity
1. Intestinal microflora, short-chain and cellular fatty acids; influence of a probiotic Florastor® (Saccharomyces boulardii). Microbial Ecology in Health and Disease 2002; 14: 220-227. F. Girard-Pipau, A. Pompel, S. Schneider, J. L. Nano, X. Herbuterne, P. Boquet, P. Rampal. S. boulardii given orally leads to a significant increase in the total amount of short chain fatty acids…[Download Entire Article] [opens a new window].
Antitoxinic activity
1. Florastor® (Saccharomyces boulardii) inhibits secretagogue-mediated adenosine 3’, 5’-cyclic monophosphate induction in intestinal cells. Gastroenterology 1994; 106: 65-72. D. Czerucka, I. Roux, P. Rampal. Florastor® (Saccharomyces boulardii) slowed the total secretion of water and electrolytes by acting on…[Download Entire Article] [opens a new window].
2. Florastor® (Saccharomyces boulardii) inhibits Clostridium difficile Toxin A binding and enterotoxicity in rat ileum. Gastroenterology; 1993: 104: 1108-1115. C. Pothoulakis, C. P. Kelly, M. A. Joshi, N. Gao, C. J. O'Keane, I. Castagliuolo, J. T. Lamont. The main finding of this study is that Florastor® (Saccharomyces boulardii) inhibits C. difficile toxin A…[Download Entire Article] [opens a new window].
3. Effect of Florastor (Saccharomyces boulardii) on cholera induced toxin cAMP level in rat epithelial cell lines. Gastroenterologie Clinique Biologie; 1989: 3: 383-387. D. Czerucka, J. L. Nano, P. Bernasconi, P. Rampal. Cholera toxin acts in vivo by activating intestinal adenylate cyclase. This study was designed to determine whether normal rat epithelial intestinal cell lines…[Download Entire Article] [opens a new window].
4. Effect of Florastor® (Saccharomyces boulardii) on water and sodium secretions induced by cholera toxin. Gastroenterologie Clinique Biologie; 1986: 10: 13-16. N. Vidon, B. Huchet, J. C. Rambaud. The effects of a suspension of Saccharomyces boulardii cells on water and sodium secretion induced by cholera toxin was measured in male wistar rats weighing 220-260 g, using the…[Download Entire Article] [opens a new window].
Enhancement of immune defenses
1. Stimulation of secretory-IgA and secretory component of immunoglobulins in small intestine of rats treated with Florastor® (Saccharomyces boulardii). Digestive Diseases and Sciences 1990; 35: 2: 251-256. J-P. Buts, P. Bernasconi, J-P. Vaerman, C. Dive. To study the mechanisms of the protective effect of S. b. against enteral pathogen infection, we assessed the response of the intestinal secretion of secretory IgA (s-IgA) and of the secretory component of immunoglobulins to oral administration… [Download Entire Article] [opens a new window].

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