Brain and Nerve Impairment
Attention Deficit Disorder (ADD), schizophrenia, depression, and autism have all shown dramatic improvements in 50% or more of cases when they supplemented with high doses of Vitamin B-6.1
Chelation/Heavy Metal Detox
Heavy metal detoxification creates oxidative stress thus increasing the body’s need for B-vitamins.
Candida/Yeast
Pantethine helps the body get rid of yeast overgrowths and accumulations in the liver of other toxic substances such as formaldehyde.
Emotional Disturbances
Thiamin (B-1) deficiency often manifests itself as aggressive and addictive behavior as well as personality disorders and mental illnesses. Up to 30% of the people admitted to hospital psychiatric wards are deficient in B-1 according to research estimates. A dose of 400mg daily helps maintain healthy levels of the brain chemicals such as acetylcholine. Also, B-6 plays a pivotal role in the feeling of well-being, in that it makes norepinephrine and serotonin brain chemicals.
Female Health
B-Complex vitamins are helpful in the treatment of PMS through their role in promoting female hormonal balance and liver detoxification.
Lead Poisoning
B-1 has the ability to counteract lead poisoning, the #1 environmental hazard that American children face, causing learning difficulties, nerve damage, and other neurological problems. Even a lightly lower than adequate B-1 level permits more lead to build up , but supplementation helps to decrease the accumulation.
Learning Disabilities & Mental Function
B-1 can help children with deficiencies and expand their learning capacity up to 25 percent2. Some behavioral problems have disappeared completely. Higher doses can enable the mentally retarded to concentrate better and make greater use of their mental abilities3. College students given 50mg of thiamin daily for two months showed faster reaction times and were found to e more clearheaded, composed, and energetic.4 Also, B-12 is critical for cognitive function as revealed by numerous test scores vs. blood levels in the elderly.5
Schizophrenia
Niacin and niacinamide (B-3) has been found to double the two-year recovery rates of schizophrenia after just five weeks.6 And, has a gently tranquilizing effect often prescribed for anxiety.
Biochemical rolls of B Vitamins
As coenzymes, the B vitamins are essential components in most major metabolic reactions. As water-soluble substances, B vitamins are not generally stored in the body in any appreciable amounts (with the exception of vitamin B-12). Therefore, the body needs an adequate supply of B vitamins on a daily basis. Vitamin B-1 (thiamin), vitamin B-2 (riboflavin), and niacinamide are all essential coenzymes in energy production. Thiamin is required for the energetics of the glycolytic and Citric Acid Cycle reactions. Thiamin is also related to nerve impulse transmission. Riboflavin is a component of coenzymes FAD and FMN, which are intermediates in many redox reactions, including energy production and cellular respiration reactions. Niacin is a component of the coenzymes NAD and NADP, which are also integral components of energy production reactions. Vitamin B-6 dependent enzymes are required for the biosynthesis of many neurotransmitters, including serotonin, epinephrine, and norepinephrine. Vitamin B-6, a coenzyme in amino acid metabolism, is also necessary for the processing of homocysteine and the conversion of tryptophan into niacin. Folic acid together with vitamin B-12 serves as a methyl donor for biosynthetic reactions, including the conversion of homocysteine to methionine. Optimum metabolism of proteins, carbohydrates, and fats depends upon adequate levels of biotin and pantothenic acid. Biotin is essential for many metabolic carboxylation reactions, while pantothenic acid, as part of Coenzyme A, is essential to energy production via the Citric Acid Cycle. While not truly vitamins, choline, inositol, and para-aminobenzoic acid are important, related nutrients to B vitamins. Choline serves not only as a methyl donor for homocysteine metabolism following conversion to betaine, but also as a structural component of cellular membranes as phosphatidylcholine and of the neurotransmitter acetylcholine. Inositol aids in the cellular response to hormonal signals, serves as a source of arachidonic acid, and is active in cellular membranes as phoshatidylinositol. Finally, para-aminobenzoic acid (PABA) is an integral component of folic acid as well as having antioxidant properties.
1 Rimland, B., Autism Research Review International, 1996:10(3):3
1 Selhub J, Bagley LC, Miller J, et al. B vitamins, homocysteine, and neurocognitive function in the elderly. Am J Clin Nutr 2000;71: 6:7-17614S-620S.
2 Harrell, R., Effect of Added Thiamin on Learning, 1973; New York: AMS Press.
3 Brotzman, G., Journal of the American Board of Family Practice, May-June 1992; 5(3): 323-25.
4 Benton, D., et al, Psychopharmacology, 1997; 129: 66-71.
5 Bell, I., Nutrition Report, 1991; 9:1-8
6 Hoffer. A., et al. Putting it All Together, 1996: New Canaan, Conn: Keats Publishing.
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